The two products are really hard to compare because their so different. SmarterMail is used not only in small businesses and small hosting companies like mailenable, but it is also in some of the largest hosting companies in the industry due to its stability and scalability. Although mailenable has many features, the enhanced aspects of SmarterMail which include: Intrusion Detection, the multitude of SPAM integration options, very refined web interfaces for administrators and end-users, outlook and pocket pc integration, reporting and many others items are significantly different or in some cases don't exist in mailenable.
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